KHOI TRAN

1. An efficient approach for the synthesis of 2'-hydroxyflavone derivatives
Author(s): Trong Binh Tran, Thi Hoa Le, Thi Thuy Luyen Nguyen, Tan Minh Khoi Tran, Khanh Hung Nguyen, Le Quan Tran, Huy Du Nguyen

ABSTRACT: The findings from the implementation of three different dehydrogenation conditions on a series of flavanones indicate that the dehydrogenation of MOM-protected 2'-hydroxyflavanones utilizing iodine/glucose in pyridine is an effective approach for synthesizing 2'-hydroxyflavanone derivatives. According to this studies, iodine was used as an iodinated agent which catalyzes the dehydrogenation process, pyridine acts as a base ligand of iodonium (I), and glucose can also act as a ketone ligand of iodonium (I). The interaction between iodonium and glucose will influence the catalytic activity and the concentration of iodonium.

2. Analysis and Evaluation of Antidiabetic Related Activities (PTP1B, α-Glucosidase, Glucose Uptake) of Erythrina Variegata L. Extracts
Author(s): Tran Tan Minh Khoi, Nguyen Phi Hung

ABSTRACT: Diabetes mellitus type 2 (T2DM) is one of the major health issues of our time, while Erythrina variegata L. (in Vietnamese, Vong nem) is a plant of considerable therapeutic promising potential. This study aims to assess optimized, particularly enriched extract from E. variegata for its multi-target antidiabetic potential. A refined method of extraction and enrichment was developed and applied. Three in vitro assays were performed: inhibition of protein tyrosine phosphatase 1B (PTP1B), inhibition of αglucosidase, and glucose uptake assays using 2-NBDG in 3T3-L1 adipocytes. The enrichment process greatly improved the biological activities of the extracts. The enriched extract E. variegata possessed an even more potent inhibition of both PTP1B (IC50 = 39.3 ± 1.7 µg/mL) and α-glucosidase (IC50 = 78.4 ± 1.1 µg/mL) compared to the crude extract as well as the positive control Acarbose (IC50 = 123.5 ± 1.0 µg/mL). Moreover, the enriched extract also enhanced glucose uptake (Relative Fluorescence Unit - RFU = 82,655 ± 2,113), which is comparable to the positive control Ursolic Acid (RFU = 81,473 ± 1,720). The enriched extract of E. variegata showcases a potent, multi-targeted antidiabetic action in vitro which invites additional analysis as a phytomedicinal candidate for the treatment of T2DM.